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KMID : 1130620120080030235
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Journal of Clinical Neurology
2012 Volume.8 No. 3 p.235 ~ p.237
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A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome
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Kim Jee-Ae
Lim Young-Min
Jang Eun-Hye
Kim Kwang-Kuk
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Abstract
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Background: The coexistence of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) is very rare and remains controversial.
Case Report: A 48-year-old woman initially presented with noticeable right ptosis and intermittent diplopia. She then developed fluctuating proximal limb weakness and difficulty in swallowing. The serum titer of anti-acetylcholine-receptor antibody was elevated and the edrophonium (Tensilon) test was positive. However, repetitive nerve stimulation revealed abnormalities typical of LEMS. The patient exhibited a good response to treatment with anticholinesterase inhibitors and steroids, and long-term evaluation disclosed that she presented with the clinical, electrophysiological, and immunological characteristics of both diseases.
Conclusions: The reported clinical and electrophysiological features suggest that this patient was a very rare case of combined MG and LEMS.
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KEYWORD
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myasthenia gravis, Lambert-Eaton myasthenic syndrome, overlap syndrome, repetitive nerve stimulation tests
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